Antimigraine drugs are medications intended to reduce the effects or intensity of migraine headache. They include drugs for the treatment of acute migraine symptoms as well as drugs for the prevention of migraine attacks.
Antimigraine drugs are medicines used to prevent or reduce the severity of migraine headache. Migraines are different from other headaches because they occur with symptoms such as nausea, vomiting, or sensitivity to light.
Antimigraine drugs or drugs that prevent migraine or cure migraine include follows: triptans, β-blockers, anticonvulsants, methysergid, calcium channel blockers, antidepressants, clonidine (α-blocker), and pizotifen and its analogs, NSAIDs.
The antimigraine drug sumatriptan, which is a serotonin-1 agonist, has commonly been associated with chest pain and myocardial infarction presumably due to vasoconstriction of the coronary arteries. Sumatriptan-induced atrial fibrillation is uncommon, but several cases have been reported with positive rechallenge, which means occurrence of an anticipated adverse drug reaction after administering sumatriptan. In vivo sumatriptan causes rapid constriction of dural and meningeal vessels. During migraine attack, it does not modify cerebral blood flow but constricts arteriovenous anastamoses that may be dilated.

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