R-Cinex Capsule (Isoniazid 300mg + Rifampicin 450mg)
R-Cinex (Isoniazid and Rifampicin) is an antibiotic medicine that belongs to a class of drugs called Anti-Tuberculosis Drugs. Anti-tuberculosis drugs are used for the treatment of infectious tuberculosis. It is essential to continue treatment with this medicine even if you feel better. Do not stop the use of this medicine without consulting your doctor.
What is R-Cinex Capsule used for?
R-Cinex is used as a first-line treatment of active Tuberculosis, along with other drugs. It is used as a monotherapy for the prevention of tuberculosis in patients exposed to the active disease.
How does R-Cinex Capsule work?
R-Cinex Capsule is a combination of two drugs: Rifampicin and Isoniazid. Rifampicin works by inactivating a bacterial enzyme (RNA-polymerase) which is required by TB bacteria to make essential proteins and to reproduce. Isoniazid is an antibiotic which prevents the Tuberculosis bacteria from forming their own protective covering. Together, they kill the bacteria and eradicate the infection.
How to take R-Cinex Capsule?
• R-Cinex is usually taken orally once per day or as instructed by a doctor.
• Swallow it as a whole. Do not chew, crush, or break it.
• Take this medication in the dose and duration as directed by your doctor.
• R-Cinex Capsule is to be taken empty stomach. Avoid R-Cinex Capsule with tyramine-rich food such as cheese, smoked fish, meats, and some types of beer.
What are the side effects of R-Cinex Capsule?
This is not an exhaustive listing of side effects. Please inform your doctor if you experience any adverse reaction to the medication.
• Dark colored urine
• Increased liver enzymes
• Peripheral neuropathy (tingling and numbness of feet and hand)
R-Cinex Capsule related warnings
R-Cinex Capsule may cause symptoms such as flushing, increased heartbeat, nausea, thirst, chest pain, and low blood pressure with alcohol (Disulfiram reactions).
R-Cinex Capsule may be unsafe to use during pregnancy. All the risks and benefits should be discussed with the physician before using this drug.
This medicine is not prescribed for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before using this drug. Your doctor may inform you to discontinue breastfeeding or to discontinue the drug based on your clinical condition.
Do not drive unless you are feeling well.
R-Cinex Capsule can cause fits, mental health problems, and optic neuritis (inflammation of the optic nerve that may cause loss of vision.) This may affect your driving ability.
R-Cinex Capsule should be used with caution in patients with kidney disease. Dose adjustment of R-Cinex Capsule may be required. Please consult your doctor.
R-Cinex Capsule should be used with caution in patients with liver disease. Dose adjustment of R-Cinex Capsule may be required. Please consult your doctor.
Use of R-Cinex Capsule is not prescribed in patients with severe liver disease.
Recommended: 450 mg of rifampicin and 300 mg of isoniazid for patients weighing less than 50 kg and 600 mg of rifampicin and 300 mg of isoniazid for patients weighing more than or equal to 50 kg.
Recommended: 450 mg of rifampicin and 300 mg of isoniazid for elderly patients weighing less than 50 kg and 600 mg of rifampicin and 300 mg of isoniazid for elderly patients weighing more than or equal to 50 kg.
Q: Is rifampin a strong antibiotic?
A: Rifampin is in a group of drugs called antimycobacterials. It works by killing the bacteria that cause infection. Antibiotics such as rifampin will not work for colds, flu, or other viral infections.
Q: How long should rifampin be taken?
A: If you have TB, you might have to take rifampin every day for several months. It is essential that you do not miss any doses. Take the capsule on an empty stomach, 1 hour before or 2 hours after a meal, with a full of glass water. It is essential to take this medicine on a regular schedule.
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